107-04 ScienCell 重组人神经营养蛋白-4 rhNT-4,Recombinant Human Neurotrophin-4
ScienCell 研究实验室(ScienCell)是一家生物技术公司,其使命是实验和治疗用细胞和细胞相关产品的研究和发展。 ScienCell为研究界提供各种高质量的正常的人类和动物细胞,细胞培养基和试剂,培养基添加因子,细胞来源的RNA,cDNA和蛋白质。ScienCell的科学家们以改善生活质量,实现细胞的能力,打击人类退化性疾病为目的研究和开发各种细胞治疗策略。ScienCell总部设在美国加利福尼亚州圣地亚哥,公司成立于1999年。
北京诺博莱德作为ScienCell品牌的特约经销商,为客户提供,正规进口,货期稳定,折扣好的服务标准。
107-04 ScienCell重组人神经营养蛋白-4 rhNT-4,Recombinant Human Neurotrophin-4,产品简介:
产品品牌; ScienCell
产品货号:107-04
产品名称:107-04 ScienCell重组人神经营养蛋白-4 rhNT-4,Recombinant Human Neurotrophin-4
产品规格:2ug
ScienCell提供纯化的、高质量的生长因子,为您的研究助力。一些专门的信号分子,在细胞的增殖和分化中发挥核心作用。只有高纯度的因子才能实现信号通路的高强度活化。 ScienCell提供的生长因子具有以下特性:高活性,少量的蛋白即有很强效应;高纯度,污染物少,干扰小。
107-04 ScienCell重组人神经营养蛋白-4 rhNT-4,Recombinant Human Neurotrophin-4, 产品说明:
神经营养因子-4(NT-4)是NGF家族神经元和上皮生长因子的成员。神经营养因子有六个保守的半胱氨酸残基,参与三个二硫键的形成。人类NT-4与人类β-NGF,BDNF和NT-3共享48-52%氨基酸(aa)序列同一性。它分别与小鼠和大鼠NT-4 / 5共享91%和95%的同一性。成熟蛋白以同源二聚体的形式分泌,也可与BDNF或NT-3形成异二聚体。NT-4结合并诱导受体二聚化和TrkB的活化.NT-4促进选定的外周和CNS神经元的发育和存活。NT-4诱导的TrkB信号传导增强NMDA受体活性并增加神经元对兴奋性毒性细胞死亡的敏感性。它还促进角质形成细胞的增殖,并在毛囊周期中加速毛囊消退。NT-4由活化的T细胞和粒细胞在炎症部位分泌,有助于组织再生。
Neurotrophin-4 (NT-4) is a member of the NGF family of neuronal and epithelial growth factors. Neurotrophins have six conserved cysteine residues that are involved in the formation of three disulfide bonds. Human NT-4 shares 48 - 52% amino acid (aa) sequence identity with human beta-NGF, BDNF, and NT-3. It shares 91% and 95% identity with mouse and rat NT-4/5, respectively. The mature protein is secreted as a homodimer and can also form heterodimers with BDNF or NT-3. NT-4 binds and induces receptor dimerization and activation of TrkB. NT-4 promotes the development and survival of selected peripheral and CNS neurons. NT-4 induced TrkB signaling augments NMDA receptor activity and increases neuronal sensitivity to excitotoxic cell death. It also promotes the proliferation of keratinocytes and accelerates hair follicle regression during the follicular cycle. NT-4 is secreted by activated T cells and granulocytes at sites of inflammation where it contributes to tissue regeneration.
ScienCell生长添加物产品订购信息:
102-01 重组人干细胞因子 rhSCF,Recombinant Human Stem Cell Factor 2ug
102-02 重组人粒细胞集落刺激因子 rhG-CSF,Recombinant Human Granulocyte Colony Stimulating Factor 2ug
102-03 重组人粒细胞巨噬细胞集落刺激因子 rhM-CSF,Recombinant Human Granulocyte Macrophage Colony Stimulating Factor 5ug
102-09 重组人巨噬细胞集落刺激因子 rhM-CSF,Recombinant Human Macrophage Colony Stimulating Factor 2ug
103-01 重组人肿瘤坏死因子-alpha rhTNF-α,Recombinant Human Tumor Necrosis Factor-alpha 10ug
103-01H 重组人肿瘤坏死因子-alpha,rhTNF--His,Recombinant Human Tumor Necrosis Factor-alpha, His 10ug
103-01v 重组人肿瘤坏死因子-alpha,Variant rhTNF-α variant,Recombinant Human Tumor Necrosis Factor-alpha Variant 10ug
103-04 重组人B细胞激活因子 rhBAFF,Recombinant Human B Cell Activating Factor 5ug
103-08 重组人制瘤素-M227a.a. rhOSM,Recombinant Human Oncostatin-M 227a.a. 2ug
103-08T 重组人制瘤素-M209a.a.,Recombinant Human Oncostatin-M209a.a 2ug
103-09 重组人血管生成抑制因子K1-3 rhAngiostatin K1-3,Recombinant Human Angiostatin K1-3 10ug
103-12 重组人血管内皮抑制素 rhEndostatin,Recombinant Human Endostatin 20ug
104-01 重组人成纤维细胞生长因子-acidic rhaFGF,Recombinant Human Fibroblast Growth Factor-acidic 10ug
104-02 重组人成纤维细胞生长因子-basic rhbFGF,Recombinant Human Fibroblast Growth Factor-basic 10ug
104-07 重组人角质细胞生长因子 rhKGF-1,Recombinant Human Keratinocyte Growth Factor-1 2ug
104-09 重组人成纤维细胞生长因子-9 rhFGF-9,Recombinant Human Fibroblast Growth Factor-9 5ug
104-10 重组人角质细胞生长因子-2 rhKGF-2,Recombinant Human Keratinocyte Growth Factor-2 5ug
104-19 重组人成纤维细胞生长因子-19 rhFGF-19,Recombinant Human Fibroblast Growth Factor-19 5ug
104-21 重组人成纤维细胞生长因子-21 rhFGF-21,Recombinant Human Fibroblast Growth Factor-21 5ug
105-01 重组人胰岛素生长因子-1 rhIGF-1,Recombinant Human IGF-I 20ug
105-01B 重组人DES(1-3)胰岛素生长因子-1 rhIGF-BP3,Recombinant Human DES (1-3) IGF-1 20ug
105-01B3重组人胰岛素生长因子-BP3,Recombinant Human IGF-BP3 5ug
105-03 重组人longR3胰岛素生长因子-1 rhLR3IGF-1,Recombinant Human Long R3 Insulin-like Growth Factor-1 20ug
105-04 重组人表皮生长因子 rhEGF,Recombinant Human Epidermal Growth Factor, 100 ug 100ug
105-05 重组人血管内皮生长因子-165 rhVEGF165,Recombinant Human VEGF165 2ug
106-06 重组人干扰素γ rhIFN-γ,Recombinant Human Interferon-gamma 20ug
107-04 重组人神经营养蛋白-4 rhNT-4,Recombinant Human Neurotrophin-4 2ug
107-08 重组人纤毛神经营养因子 rhCNTF,Recombinant Human Ciliary Neurotrophic Factor 5ug
107-10 重组人神经调节蛋白 rhBTC,Recombinant Human NRG-1 EGF-like domain 10ug
107-11 重组人ErbB3片段 rhErbB3-f,Recombinant Human ErbB3 Fragment 5ug
107-12 重组人β动物纤维 rhBTC,Recombinant Human Betacellulin 5ug
108-02 重组人骨形成蛋白-2 rhBMP-2,Recombinant Human Bone Morphogenetic Protein-2 2ug
108-04 重组人骨形成蛋白-4 rhBMP-4,Recombinant Human Bone Morphogenetic Protein-4 2ug
108-07 重组人骨形成蛋白-7 rhBMP-7,Recombinant Human Bone Morphogenetic Protein-7 2ug
108-08 重组人骨保护素 rHuOPG-Fc,Recombinant Human Osteoprotegerin/Fc Chimera 10ug
108-09 重组人NOGGIN蛋白 rhNOGGIN,Recombinant Human NOGGIN 5ug
301-01 重组人生长激素 rhGF,Recombinant Human Growth Hormone 20ug