103-01v ScienCell 重组人肿瘤坏死因子-alpha,Variant rhTNF-α variant,Recombinant Human Tumor Necrosis Factor-alpha Variant
ScienCell 研究实验室(ScienCell)是一家生物技术公司,其使命是实验和治疗用细胞和细胞相关产品的研究和发展。 ScienCell为研究界提供各种高质量的正常的人类和动物细胞,细胞培养基和试剂,培养基添加因子,细胞来源的RNA,cDNA和蛋白质。ScienCell的科学家们以改善生活质量,实现细胞的能力,打击人类退化性疾病为目的研究和开发各种细胞治疗策略。ScienCell总部设在美国加利福尼亚州圣地亚哥,公司成立于1999年。
北京诺博莱德作为ScienCell品牌的特约经销商,为客户提供,正规进口,货期稳定,折扣好的服务标准。
103-01v ScienCell重组人肿瘤坏死因子-alpha,Variant rhTNF-α variant,Recombinant Human Tumor Necrosis Factor-alpha Variant,产品简介:
产品品牌; ScienCell
产品货号:103-01v
产品名称:103-01v ScienCell重组人肿瘤坏死因子-alpha,Variant rhTNF-α variant,Recombinant Human Tumor Necrosis Factor-alpha Variant
产品规格:10ug
ScienCell提供纯化的、高质量的生长因子,为您的研究助力。一些专门的信号分子,在细胞的增殖和分化中发挥核心作用。只有高纯度的因子才能实现信号通路的高强度活化。 ScienCell提供的生长因子具有以下特性:高活性,少量的蛋白即有很强效应;高纯度,污染物少,干扰小。
103-01v ScienCell重组人肿瘤坏死因子-alpha,Variant rhTNF-α variant,Recombinant Human Tumor Necrosis Factor-alpha Variant, 产品说明:
TNF-α的强效抗肿瘤活性的临床应用受到促炎副作用的限制,包括发热、剂量限制性低血压、肝毒性、血管内血栓形成和出血。设计临床适用的具有低全身毒性的TNF-α突变体一直是药理学的强烈兴趣。与小鼠TNF-α结合的小鼠TNF-相比,人TNF-α与小鼠TNF-α55结合但不与小鼠TNF-α75结合,在小鼠中表现出保留的抗肿瘤活性和降低的全身毒性。基于这些结果,已经设计了许多选择性结合TNF-α55的TNF-α突变体。这些突变体在体外对肿瘤细胞系表现出细胞毒性活性,并且在体内表现出较低的全身毒性。
The clinical use of the potent antitumor activity of TNF-α has been limited by the proinflammatory side effects including fever, dose-limiting hypotension, hepatotoxicity, intravascular thrombosis, and hemorrhage. Designing clinically applicable TNF-α mutants with low systemic toxicity has been an intense pharmacological interest. Human TNF-α, which binds to the murine TNF-α55 but not to the murine TNF-α75, exhibits retained antitumor activity and reduced systemic toxicity in mice compared with murine TNF-α, which binds to both murine TNF receptors. Based on these results, many TNF-α mutants that selectively bind to TNF-α55 have been designed. These mutants displayed cytotoxic activities on tumor cell lines in vitro, and exhibited lower systemic toxicity in vivo.
ScienCell生长添加物产品订购信息:
102-01 重组人干细胞因子 rhSCF,Recombinant Human Stem Cell Factor 2ug
102-02 重组人粒细胞集落刺激因子 rhG-CSF,Recombinant Human Granulocyte Colony Stimulating Factor 2ug
102-03 重组人粒细胞巨噬细胞集落刺激因子 rhM-CSF,Recombinant Human Granulocyte Macrophage Colony Stimulating Factor 5ug
102-09 重组人巨噬细胞集落刺激因子 rhM-CSF,Recombinant Human Macrophage Colony Stimulating Factor 2ug
103-01 重组人肿瘤坏死因子-alpha rhTNF-α,Recombinant Human Tumor Necrosis Factor-alpha 10ug
103-01H 重组人肿瘤坏死因子-alpha,rhTNF--His,Recombinant Human Tumor Necrosis Factor-alpha, His 10ug
103-01v 重组人肿瘤坏死因子-alpha,Variant rhTNF-α variant,Recombinant Human Tumor Necrosis Factor-alpha Variant 10ug
103-04 重组人B细胞激活因子 rhBAFF,Recombinant Human B Cell Activating Factor 5ug
103-08 重组人制瘤素-M227a.a. rhOSM,Recombinant Human Oncostatin-M 227a.a. 2ug
103-08T 重组人制瘤素-M209a.a.,Recombinant Human Oncostatin-M209a.a 2ug
103-09 重组人血管生成抑制因子K1-3 rhAngiostatin K1-3,Recombinant Human Angiostatin K1-3 10ug
103-12 重组人血管内皮抑制素 rhEndostatin,Recombinant Human Endostatin 20ug
104-01 重组人成纤维细胞生长因子-acidic rhaFGF,Recombinant Human Fibroblast Growth Factor-acidic 10ug
104-02 重组人成纤维细胞生长因子-basic rhbFGF,Recombinant Human Fibroblast Growth Factor-basic 10ug
104-07 重组人角质细胞生长因子 rhKGF-1,Recombinant Human Keratinocyte Growth Factor-1 2ug
104-09 重组人成纤维细胞生长因子-9 rhFGF-9,Recombinant Human Fibroblast Growth Factor-9 5ug
104-10 重组人角质细胞生长因子-2 rhKGF-2,Recombinant Human Keratinocyte Growth Factor-2 5ug
104-19 重组人成纤维细胞生长因子-19 rhFGF-19,Recombinant Human Fibroblast Growth Factor-19 5ug
104-21 重组人成纤维细胞生长因子-21 rhFGF-21,Recombinant Human Fibroblast Growth Factor-21 5ug
105-01 重组人胰岛素生长因子-1 rhIGF-1,Recombinant Human IGF-I 20ug
105-01B 重组人DES(1-3)胰岛素生长因子-1 rhIGF-BP3,Recombinant Human DES (1-3) IGF-1 20ug
105-01B3重组人胰岛素生长因子-BP3,Recombinant Human IGF-BP3 5ug
105-03 重组人longR3胰岛素生长因子-1 rhLR3IGF-1,Recombinant Human Long R3 Insulin-like Growth Factor-1 20ug
105-04 重组人表皮生长因子 rhEGF,Recombinant Human Epidermal Growth Factor, 100 ug 100ug
105-05 重组人血管内皮生长因子-165 rhVEGF165,Recombinant Human VEGF165 2ug
106-06 重组人干扰素γ rhIFN-γ,Recombinant Human Interferon-gamma 20ug
107-04 重组人神经营养蛋白-4 rhNT-4,Recombinant Human Neurotrophin-4 2ug
107-08 重组人纤毛神经营养因子 rhCNTF,Recombinant Human Ciliary Neurotrophic Factor 5ug
107-10 重组人神经调节蛋白 rhBTC,Recombinant Human NRG-1 EGF-like domain 10ug
107-11 重组人ErbB3片段 rhErbB3-f,Recombinant Human ErbB3 Fragment 5ug
107-12 重组人β动物纤维 rhBTC,Recombinant Human Betacellulin 5ug
108-02 重组人骨形成蛋白-2 rhBMP-2,Recombinant Human Bone Morphogenetic Protein-2 2ug
108-04 重组人骨形成蛋白-4 rhBMP-4,Recombinant Human Bone Morphogenetic Protein-4 2ug
108-07 重组人骨形成蛋白-7 rhBMP-7,Recombinant Human Bone Morphogenetic Protein-7 2ug
108-08 重组人骨保护素 rHuOPG-Fc,Recombinant Human Osteoprotegerin/Fc Chimera 10ug
108-09 重组人NOGGIN蛋白 rhNOGGIN,Recombinant Human NOGGIN 5ug
301-01 重组人生长激素 rhGF,Recombinant Human Growth Hormone 20ug